Welcome to Department of Molecular Pharmacology & Neurobiology

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Welcome to Department of Molecular Pharmacology & Neurobiology

 The brain is made up of precisely wired neuronal circuitry with assemblies of neuronal cells that continually receive information, elaborate and perceive it, and make decisions.
 The neuronal cells use chemical substances called neurotransmitters to mediate most of the synaptic transmission in the nervous system. Synaptic transmission occurs at synapses, where the axon comes in contact with other neurons and passes information on to them. Hence proper axonal growth to appropriate synaptic targets is essential for the production of a functioning nervous system. We are interested in understanding the molecular and cellular mechanisms of the interaction between the neurotransmitters and their receptors, and the signal transduction underlying axonal guidance, transport, and synaptic plasticity.

News & Information


“Anti-Semaphorin 3A neutralization monoclonal antibody prevents sepsis development in lipopolysaccharide-treated mice ” by Yamashita et al(Int Immunol, 2015).
Research Results

”A novel Semaphorin3A signaling mediated through dynamic conformational change associated with filamin-A and CRMP1 interaction” by Nakamura et al (Nat Commun, 2014). http://www.ncbi.nlm.nih.gov/pubmed/25358863

”Life innovation and future healthcare system” presented by Prof Goshima in Smart City 2014 at Yokohama Convention Center.



The 131st Kanto Branch Meeting, Japanese Pharmacology was held in Yokohama City University, Sch of Med (Fuku-ura campus)

Chair, Prof Yoshio Goshima, MD&PhD (Dept of Mol Pharmacol&Neurobiol)

”A retrograde Sema3A signaling propagated from local growth cone regulates dendritic localization of GluA2 subunit-containing AMPA receptors ” by Yamashita et al (Nat Commun, 2014). http://www.ncbi.nlm.nih.gov/pubmed/24599038